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Dr. Lawrence Lum presents results of multiple myeloma pilot study at annual ASH meeting, exposition

Lawrence Lum, M.D., D.Sc., professor of  Oncology, Medicine and Immunology and Microbiology at Karmanos and Wayne State University School of Medicine (WSU SOM), was tapped by the American Society of Hematology (ASH) Program Committee to present research in an oral session at the recent 55th ASH Annual Meeting and Exposition in New Orleans.

The title of the research is, “Induction Of Anti-Myeloma Cellular and Humoral Immunity By Pre-Targeting Clonogenic Myeloma Cells Prior To Stem Cell Transplant With T Cells Armed With Anti-CD3 x Anti-CD20 Bispecific Antibody Leads To Transfer Of Cellular and Humoral Anti-Myeloma Immunity.” The 12-patient multiple myeloma pilot study, supported by the Leukemia & Lymphoma Society, showed that a vaccination against the patient's own myeloma cells can be transferred through a stem cell transplant and will increase specific anti-myeloma responses and overall immune responses in patients after the stem cell transplant.

Dr. Lum’s research was among the 2.5 percent of abstracts selected for presentation at the meeting and exposition, among thousands submitted for consideration. His co-authors include Archana Thakur, Ph.D.; Zaid Al-Kadhimi, M.D.; Abhinav Deol, MBBS, M.D.; Lois Ayash, M.D.; Elyse N. Tomaszewski, BA; Hiroshi Yano, BS; Dana L. Schalk, BS, MBA; Sri Vidya Kondadasula, MS; Patricia A. Steele, RN, BSN; Jeffrey A. Zonder, M.D.; Joseph P. Uberti, M.D., Ph.D.; Voravit Ratanatharathorn, M.D. and Muneer H. Abidi, M.D., of the Department of Oncology at Karmanos and WSU SOM. This work is an example of preclinical and clinical multidisciplinary efforts involving immunotherapy, bone marrow transplantation, and multiple myeloma investigators in the Department of Oncology at Karmanos and WSU SOM.

In addition to his presentation, Dr. Lum was videotaped discussing his research, which can be viewed here: http://www.cancernetwork.com/ash-2013/immunotherapy-prior-stem-cell-transplant-multiple-myeloma.

His work also is published online in the November 15 supplemental volume of Blood. Read the research presented at ASH here: https://ash.confex.com/ash/2013/webprogram/Paper61963.html

We congratulate Dr. Lum on his being chosen as a presenter at ASH!

 

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