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Karmanos Researchers Win Federal Grants to Explore Prostate, Breast Cancers, Treatment Modalities

Barbara Ann Karmanos Cancer Institute scientists have won a variety of federal grants supporting their cancer research.

Rodney D. Braun, Ph.D., associate professor of Anatomy and Cell Biology at Karmanos and Wayne State University School of Medicine (WSU SOM) has received a two-year, $332,336 grant from the National Cancer Institute for his project, “Guiding Ca2+ Channel-Based Cancer Treatment Using Mn2+-Enhanced MRI.” With this project, Dr. Braun and his colleagues will use manganese-enhanced magnetic resonance imaging to noninvasively determine the activity of different calcium channels in tumors, with the ultimate goal of eventually using the technology to guide and individualize calcium channel-based treatment of cancer.

Sreenivasa R. Chinni, Ph.D., associate professor of Urology and Pathology at Karmanos and WSU SOM, will receive a one-year, $75,000 grant from the Department of Defense for his research, “Uncarboxylated Osteocalcin and Gprc6a axis produce intratumoral androgens in castration resistant prostate cancer.” The proposed study aims to help scientists understand a novel tumor pathway leading to the expression of enzymes and the subsequent progression of castrate-resistant prostate cancer.

Bonnie Sloane, Ph.D., distinguished professor and chair of the Department of Pharmacology at Karmanos and WSU SOM, has received a two-year, $313,500 grant from the National Institutes of Health for her study, “4D Microfluidic Models for Targeting Breast Cancer: Lymphatic Interactions.” This project aims to create a new standard for in vitro analyses of the processes associated with lymphatic metastasis of breast cancers and for screening of those therapies to interfere with those processes, with the goal of identifying effective therapeutic interventions in general and for individual patients.

We congratulate Drs. Braun, Chinni and Sloane for receiving these grants!

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