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Oncology professor using R01 grant to explore origins of common adult onset diseases

Melissa Runge-Morris, M.D., professor in the Department of Oncology at the Barbara Ann Karmanos Cancer Institute and director of the Institute of Environmental Health Sciences (IEHS) at Wayne State University’s School of Medicine, was awarded a five-year, nearly $2 million R01 grant from the National Institute of Environmental Health Sciences section of the National Institutes of Health to explore determinants of susceptibility in common diseases such as diabetes, atherosclerotic heart disease and various cancers.

All of these diseases are considered to be adult-onset pathologies, but the research team is exploring the possibility of origins during early periods of human development.

Led by Dr. Runge-Morris, researchers at Wayne State, University of Alabama at Birmingham and University of Pittsburgh will work on “Expression, Regulation and Function of the SULT1C Carcinogen-Activating Enzymes."

"Our long-term goal is to understand how sulfotransferase enzymes might impact drug efficacy and safety, as well as susceptibility to environmental carcinogens and modulators of metabolic processes," said Dr. Runge-Morris.

Thomas Kocarek, Ph.D., also of IEHS and associate professor of pharmacology, is co-investigator of the project.

The project number for this National Institutes of Health R01 grant is ES022606.


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