The Phase I Program at Karmanos is focused on developing new therapies and drugs to fight cancer. It is one of just 14 National Cancer Institute-funded Phase I programs in the country, and the only one of its kind in Michigan. Many of the clinical trials offered have been developed by our own physicians and researchers. Learn more about clinical trials
and how they help cancer patients.
To offer hope and longer life to patients with all types of cancer by making available the newest types of therapy, by creating new knowledge about how these therapies fight cancer and by providing national leadership in testing these new therapies.
What is a Phase I Clinical Trial?
A typical Phase I clinical trial evaluates how a new drug should be given, either orally or injected into the blood, how often and what dosage is safe. A Phase I trial is often the first time a drug has been given to human, or the first time a new drug has been given to a human in combination with another standard cancer treatment. Because we are working with new drugs, most Phase I trials only enroll a small number of patients.
Phase I clinical trials provide the initial pieces of critical information about the effect of a new drug on humans which is necessary for future clinical development. Once the initial Phase I trial is complete, drug development may progress into larger clinical studies that continue to test the safety of the new drug and how well it works in treating a particular type of cancer.
The Phase I Team meets with and treats patients at the state-of-the-art Eisenberg Center for Translational Therapeutics, located at the Karmanos Cancer Center’s midtown Detroit campus.
Learn more about Karmanos’ Phase 1 Program
The Barbara Ann Karmanos Cancer Institute’s Patricia LoRusso, D.O., director of the Phase I Clinical Trials Program, outlines the Karmanos Phase I Clinical Trials including how patients are chosen for the Phase I Clinical Trials, how the research is funded and what makes this program unique. Watch the video.
Make a Donation
For patients with advanced cancer who have exhausted conventional treatments, Phase I clinical trials offer the last, best hope: tomorrow's drugs today.Your generous contribution will go directly to the Phase I Team to ensure patients continue to have access to the novel therapies that may increase their quality of life and give them more precious time with their loved ones. Donate Now