Interferon Pathway Genes Regulated by Methylation-dependent Silencing in Immortalization
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Gene
IMMORT
5AZA
CpG
Locus
Interferon-induced 17-kDa/15-kDa
-4.2
13.9
+
1p36.33
Interferon-inducible peptide (6-16)
-3.3
10.2
-
1p36
mRNA expressed in osteoblast
-4.3
32.5
-
1p31
Microtubular protein p44 (IFI44)
-5.5
17.8
-
1p31.1
Interferon-inducible protein  (Absent in Melanoma 2 AIM2) 
-5.3
21.6
-
1q22
Complement factor H
-6.6
6.8
-
1q32
CIG5 vipirin; similar to Inflammatory Response Protein 6
-13.9
67.0
-
2p25.3
Signal Transducer Activator of Transcription 1 STAT1 91kDa
-1.9
7.6
+
2q32.2
TNF-related apoptosis inducing ligand; TRAIL
-6.7
42.2
-
3q26
Cytokine (GRO-beta GRO-2) 
-12.9
29.6
+
4q12-13
Interleukin 8
-15.5
92.7
-
4q12-13
Melanoma growth stimulatory activity (MGSA) (GRO-1)
-146.3
64.6
+
4q21
HLA class I locus C heavy chain
-4.1
5.7
+
6p21
HLA-F; gene for major histocompatibility complex class I F *
-8.9
29.4
+
6q21.3
uPA gene (urokinase-plasminogen activator gene) 
-14.6
4.4
+
8p12
Ly-6-related protein (9804) gene
-73.7
34.1
+
8q24.3
Tripartite motif-containing protein 14 TRIM14
-4.3
6.2
+
9q22-q31
PCTAIRE 2 (pctaire protein kinase)
-13.7
19.3
+
9q22.33
Dickkopf-1 (hdkk-1)
-8.3
14.4
-
10q11.2
CIG49 Interferon-induced protein with tetratricopeptide repeats 4 
-12.8
70.2
-
10q24
DUSP5 (dual specificity MAP kinase-phosphatase)*
-8.9
12.6
+
10q25
Interferon-inducible 56 kDa protein
-8.6
36.6
-
10q25-q26
Interferon-inducible membrane protein  9-27  (IFITM1)
-11.8
8.8
-
11p15.5
Interferon  regulatory  factor  7
-6.3
17.5
+
11p15.5
DUSP6 (dual specificity MAP kinase-phosphatase)
-4.7
4.6
+
12q22-q23
(2-5') oligoadenylate synthetase  p46/p42  E  gene    OAS-1
 -15.4
76.5
-
12q24.1
(2-5') oligoadenylate synthetase  59  kDa isoform     OAS-L 
-7.4
40.0
-
12q24.2
(2-5') oligoadenylate synthetase  69/71  kDa isoform OAS-2
 -2.7
19.6
-
12q24.2
Interferon alpha-inducible protein 27
-13.0
482.0
-
14q32
HEM45  ISG-20
-21.7
50.2
-
15q26
NK4 protein (natural killer cell transcript 4)
-35.0
20.2
-
16p13.3
Insulin-like growth factor binding protein-4
-33.3
3.8
-
17q12-q21
K12 protein precursor (SECTM1)
-10.7
19.6
+
17q25
Gamma-interferon-inducible  protein  (IP-30)
-27.8
31.2
+
19p13.1
BST-2 (bone marrow stroma cell surface gene)
-9.9
38.7
-
19p13.2
Major group rhinovirus receptor (HRV)  ICAM
-9.3
28.9
+
19p13.3
Transglutaminase (TGase)
-50.9
144.6
+
20q12
Interferon-inducible protein p78 MX1
-75.7
162
+
21q22.3
Interferon-inducible protein MX2
-5
42
-
21q22.3

Data was processed in Affymetrix Data Mining Tool (fold change).
5AZA:        Upregulation in 5AZA-dC treated HP MDAH041 cells vs. untreated HP MDAH041 cells.
IMMORT:  Downregulation in HP MDAH041 cells vs. LP MDAH041 cells.
CpG:         + indicates that a CpG island within an interval of  –500 bp to +200 bp around the transcription starting site (TSS) of a     length of at least 200 bp using CpGPlot program (http://www.ebi.ac.uk/emboss/cpgplot/).
Locus:     indicates the chromosome position within the human genome.