p53 sequence analysis of LFS patients’ fibroblasts

Cell Line        Codon             Mutation Type
MDAH087      248  CGG  /  TGG        Arg to Trp           
MDAH172      175  CGC  /  CAC        Arg to His            
MDAH174      175  CGC  /  CAC        Arg to His            
MAT170-1     133  ATG  /  ACG        Met to Thr            
MAT170-3     133  ATG  /  ACG        Met to Thr            
MAT120-1                 N.D.        wt by Western Blot
MDAH041      184 GAT A / GAA      Frameshift stop after      
                                         60 amino acids  
                                                                              
ND=not determined