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|
TABLE 1. Tumorigenic properties of PA-1 cells
|
|
| Cell line |
Growth in nude mice |
Latent period (wks) |
|
| Clone 1-neo |
0/3a |
>24 |
| Clone 1-AP-2 |
2/5b |
22, 26 |
| Clone 1-AP-2 |
5/6a |
16 |
| Clone 1-GAL4-AP-2 |
5/7a |
8-20 |
| Clone 1-GAL4-VP16 |
2/5b |
4, 6 |
| 9113 |
4/4 |
6 |
| 9113-zeo-PC4c |
0/2a |
>32 |
|
| a Number of cell
lines developed from independently picked G418r colonies that
formed tumors in nude mice/total number of cell lines tested. G418r
colony-derived cell lines were shown to express the transgenes by reverse
transcription-PCR. |
| b Pool of transfected
G418r colonies: number of mice bearing tumors/number of mice
injected with cells. |
| c Cell lines 9113-zeo-PC4-1
and 9113-zeo-PC4-2. Note that neither of these 9113-zeo-PC4 clones expressing
the PC4 cDNA could form tumors in nude mice. |
|