Classification of SIRT2-related genes

Gene name NCBI LocusLink IDa Human chromosomal location Protein product(s), conceptual translation PSORT protein predictions (results of the k-NN prediction)b Comments
SIRT1 23411 10q21.3 Isoform 1 (747 aa), isoform 2 (555 aa) SIRT1 (747 aa): 69.9% nuclear, 13.0% mitochondrial, 8.7% plasma membrane, 4.3% vesicles of secretory system, 4.3% cytoplasmic Known as Sir1a in mice; ortholog of the Drosophila SIRT gene located at 34A7-8; ortholog of the C. elegans SIRT gene found on chromosome IV; probable ortholog identified in zebrafish as ESTc
SIRT2 22933 19q13.1 Isoform 1 (389 aa), isoform 2 (352 aa) SIRT2 (352 aa): 30.4% cytoplasmic, 21.7% mitochondrial, 17.4% extracellular (including cell wall), 17.4% nuclear, 4.3% cytoskeletal, 4.3% vacuolar, 4.3% endoplasmic reticulum Known as SIR2L2 in mice ortholog of the Drosophila SIRT gene found on 3R92E; no apparent ortholog in C. elegans
SIRT3 23410 11p15.5 Isoform A, (257 aa), isoform B (346 aa) SIRT3 (399 aa): 44.4% endoplasmic reticulum, 22.2% Golgi, 11.1% mitochondrial, 11.1% nuclear, 11.1% cytoplasmic Known as SIR2L3 in mice; no apparent ortholog in Drosophila or C. elegans
SIRT4 23409 12q 314 aa SIRT4 (314 aa): 33.3% endoplasmic reticulum, 22.2% vacuolar, 22.2% plasma membrane, 11.1% Golgi, 11.1% mitochondrial Drosophila ortholog found at 65E5-6 on chromosome 3; in C. elegans there are 2 closely linked apparent orthologs on chromosome
SIRT5 23408 6pter-p25.1 Isoform 1 (310 aa), isoform 2 (299 aa) SIRT5 (310 aa): 65.2% mitochondrial, 8.7% cytoplasmic, 8.7% nuclear, 4.3% vacuolar, 4.3% extracellular (including cell wall) 4.3% plasma membrane, 4.3% peroxisomal No apparent orthologs in either Drosophila or C. elegans
SIRT6 51548 19p13.3 Isoform 1 (355 aa), isoform 2 (237 aa) SIRT6 (355 aa): 78.3% nuclear, 13.0% cytoskeletal, 4.3% Golgi, 4.3% mitochondrial Drosophila ortholog found at 3R 85F-86A; apparent C. elegans ortholog found on chromosome I
SIRT7 51547 17q25 400 aa SIRT7 (400 aa): 56.5% nuclear, 26.1% cytoplasmic, 13.0% mitochondrial, 4.3% cytoskeletal No apparent orthologs in either Drosophila or C. elegans

a LocusLink ID is available from the electronic repository at the National Center for Biolotechnology Information (NCBI), available at http://www.ncbi.nlm.nih.gov/LocusLink.

b PSORT prediction is a summation of results of the k-nearest neighbor (k-NN) prediction according to the predictive software accessible at http://psort.nibb.ac.jp/form2.html.

c EST, expressed sequence tag.

Click here for Amino Acid Alignment