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  • A Phase 1b/2a, Multicenter, Open-Label Study of Pocenbrodib as Monotherapy and in Combination with Abiraterone Acetate, Olaparib, or 177Lu-PSMA-617 in Participants with Metastatic Castration-Resistant Prostate Cancer (mCRPC)

    Karmanos Trial ID
    • 2025-020
    NCT ID
    • NCT06785636
    Age Group
    • Adult
    Scope
    • National
    PhaseClick for Clinical Trial Phase DefinitionPhase I
    Includes initial studies to determine the metabolism and pharmacologic actions of drugs in humans, the side effects associated with increasing doses, and to gain early evidence of effectiveness; may include healthy participants and/or patients.
    • Phase I/II
    Principal Investigator
    • Cackowski, Frank

    Objective:

    Primary Objectives:

    Phase 1b:

    • Confirm the safety and tolerability of pocenbrodib monotherapy in men with mCRPC
    • Determine the RP2D of pocenbrodib as monotherapy in men with mCRPC

    Phase 2a:

    • Evaluate the clinical activity of pocenbrodib in men with mCRPC as monotherapy and in combination with abiraterone acetate, olaparib, or lutetium Lu 177 vipivotide tetraxetan (177Lu-PSMA-617)

    Secondary objectives:

    Phase 1b and Phase 2a:

    • Characterize the PK of pocenbrodib in men with mCRPC
    • Evaluate the relationship between exposure to pocenbrodib and effect (response, safety, and/or resistance)
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    Karmanos Cancer Institute - Detroit Headquarters

    4100 John R
    Detroit, MI 48201
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    Phone: 1-800-527-6266

    Karmanos Cancer Institute at Weisberg Cancer Center - Farmington Hills

    31995 Northwestern Hwy
    Farmington Hills, MI 48334
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