A Phase 1, open-label, dose-escalation and dose-expansion study evaluating AO-252, a protein-protein interaction inhibitor of TACC3, in advanced solid tumors including triple negative breast cancer (TNBC), high-grade serous ovarian carcinoma (HGSOC), and endometrial cancer

Cancer Categories

Karmanos Trial ID

NCT ID

Age Group

Scope

Phase

Principal Investigator

Ira
Winer, M.D., Ph.D., FACOG
Oncology - Gynecologic, Oncology - Surgical View Profile

Primary Objective:

The primary objectives of this study are to determine the MTD/RP2D and safety profile of
AO-252 in patients with advanced TNBC, HGSOC, and endometrial cancer

Secondary Objectives:

Determine antitumor activity of AO-252 as assessed by objective response rate (ORR),
disease control rate (DCR), duration of response (DOR), time to progression (TTP), and
time to response (TTR).
Determine the pharmacokinetic (PK) profile of AO-252 including maximum plasma
concentration (Cmax), time to maximum plasma concentration (Tmax), and area under the
plasma concentration-time curve (AUC) over the dosing interval.

Eligibility

Inclusion Criteria:

Adults ≥ 18 years of age.
Patient has histologically or cytologically confirmed metastatic or locally advanced unresectable solid tumors with TP53 mutation/loss and with/without brain metastasis. Patients must have relapsed/be refractory to at least 1 line of systemic therapy in the metastatic setting (excluding melanoma).
Prostate cancer:

mCRPC with histologic confirmation of adenocarcinoma. mCRPC with neuroendocrine features or mixed histology are excluded
Patients will be enrolled irrespective of the TP53 status
Participant must have prostate specific antigen (PSA) of ≥ 2 ng/mL
Is surgically or medically castrated, with testosterone levels of less than 50 ng/dL
Patients who progressed on at least 1 prior novel androgen receptor AR-targeted therapy (that is, abiraterone acetate, apalutamide, enzalutamide, darolutamide), and or at least 1 prior systemic chemotherapy (e.g., docetaxel)

Histologically or cytologically confirmed metastatic or locally advanced unresectable solid tumors excluding melanoma with TP53 mutation/loss and tumor must have relapsed/be refractory to at least 1 line of systemic therapy. Untreated brain metastases not requiring immediate local CNS therapy
Previously treated brain metastases with progression of previous lesions or new lesions, but not requiring immediate local CNS therapy
At least one measurable untreated brain lesion ≥0.5 cm and <3.0 cm in the longest axis
Prior SRS radiosurgery (must be completed within 7 days of study treatment initiation) is allowed as long as the previous treatment volume does not overlap with the current targets.

Measurable disease per RECIST v1.1 criteria. For mCRPC patients, tumor response will be evaluated using RECIST version 1.1 (soft tissue) and PCWG-3 criteria (bone) and efficacy endpoints will also include radiographic progression-free survival (rPFS), PSA50 response and PSA progression
Adequate bone marrow reserve, cardiac, liver, and renal function:

Absolute neutrophil count (ANC) ≥ 1,500/mm3
Platelet count ≥ 100,000/mm3
Hemoglobin ≥ 9 g/dL
Bilirubin ≤ 1.5 × upper limit of normal (ULN) or direct bilirubin ≤ ULN for patients with total bilirubin levels >1.5 × ULN
Alanine aminotransferase (ALT, SGPT) and aspartate aminotransferase (AST, SGOT) ≤ 2.5 × ULN (≤ 5 × ULN if liver metastases are present)
INR ≤ 1.5 × ULN unless patient is receiving anticoagulant therapy and PT or aPTT is within therapeutic range of intended use of anticoagulants
Creatinine clearance ≥ 60 mL/min (by Cockroft Gault formula).

Female patients of child-bearing potential must have a negative serum pregnancy test and use at least 1 form of acceptable birth control method listed below as approved by the Investigator before initiating study treatment and for 3 months after the last dose of study drug.

Sterilization
Any hormonal contraceptives (non-CYP 3A4 inhibitors) associated with inhibition of ovulation
IUD (intrauterine device) or intrauterine hormone releasing system

Male patients must be sterilized or use a form of barrier contraception, such as condoms with spermicide, during the study and for 3 months after the last dose of study drug.
Life expectancy of ≥ 3 months.
Ability to provide written informed consent.
An Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 1.

Exclusion Criteria:

Patients with symptomatic brain metastases requiring treatment and/or leptomeningeal disease
Patients with a previous history of another malignancy (other than cured basal cell or squamous cell carcinoma of the skin or cured in-situ carcinoma) within 3 years of study entry.
Patients with uncontrolled pleural effusions, pericardial effusion, or ascites that do not resolve.
Patients with gastrointestinal tract disease causing the inability to take oral medication (e.g., swallowing difficulties, malabsorption syndromes, extensive small bowel resection [> 100cm], gastric bypass surgery).
Pregnant or breast-feeding patients or any patient with child-bearing potential not using adequate contraception.
Known human immunodeficiency virus, hepatitis B virus (HBV), or hepatitis C virus (HCV) infection (excluding cured HBV and/or cured HCV infection).
Presence of any serious concomitant systemic disorders incompatible with the study in the opinion of the Investigator (e.g., uncontrolled congestive heart failure, active infection).
Radiation therapy to > 30% of bone marrow within 3 months before study entry.
Patients with clinically significant autoimmune disease, either currently present of present within 2 years, including a current requirement for systemic immunosuppressive therapy equivalent to > 10 mg/prednisone daily (local immunosuppressive therapy such as inhaled or topical corticosteroids is allowed).

Patients with abnormal or clinically significant electrocardiogram (ECG) abnormality, including but not limited to a confirmed corrected QT interval using Fridericia's formula (QTcF) > 470 msec.
Patient has received systemic anticancer therapy within 3 weeks or 5 half-lives, whichever is shorter.
Patients must have recovered from all AEs due to previous therapies to ≤ Grade 1 or baseline.
Any of the following conditions (on-study testing is not required):

Known HIV-infected patients unless on effective anti-retroviral therapy with an undetectable viral load within 6 months and no opportunistic infection within the past 12 months, or b. Known or suspected hepatitis B if active infection (patients with chronic hepatitis B infection must have an undetectable HBV viral load on suppressive therapy, if indicated; positive surface antibody alone is not an exclusion), or c. Known or suspected hepatitis C infection that has not been treated and cured unless currently on treatment with an undetectable viral load.

Locations

4100 John R
Detroit, MI 48201
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Phone: 1-800-527-6266

31995 Northwestern Hwy
Farmington Hills, MI 48334
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Phone: 1-800-527-6266

Applicable Disease Site

Therapies, Drugs, Devices