Having a large clinical trial portfolio means giving patients treatment options often not available anywhere else, and years before they become the standard of care. To learn more about Karmanos Cancer Institute clinical trials or to see if a trial is right for you, please call 1-800-KARMANOS (1-800-527-6266) or request an appointment below
  • A randomised, open-label, Phase II, dose/schedule optimisation study of NUC-3373/leucovorin/irinotecan plus bevacizumab (NUFIRI-bev) versus 5-FU/leucovorin/irinotecan plus bevacizumab (FOLFIRI-bev) for the treatment of patients with previously treated unresectable metastatic colorectal cancer

    Cancer Categories
    • Gastrointestinal (GI)
    Karmanos Trial ID
    • 2022-126
    NCT ID
    • NCT05678257
    Age Group
    • Adult
    • National
    PhaseClick for Clinical Trial Phase DefinitionPhase II
    Includes controlled clinical studies conducted to evaluate the effectiveness of the drug for a particular indication or indications in participants with the disease or condition under study and to determine the common short-term side effects and risks.
    • Phase II
    Principal Investigator
    • Mohammed Najeeb
      Al Hallak, M.D., MS

      Oncology - Medical View Profile


    Primary Objectives:

    • To compare PFS of NUC-3373 in combination with LV, irinotecan and bevacizumab (NUFIRI-bev) with 5-FU in combination with LV, irinotecan and bevacizumab (FOLFIRI-bev)
    • To determine the optimal NUFIRI-bev dosing schedule

    Secondary Objectives:

    • To compare the efficacy of NUFIRI-bev to FOLFIRI-bev in terms of:
      • Objective response rate (ORR)
      • Duration of response (DoR)
      • Disease control rate (DCR)
      • Maximum percentage change in tumour size
      • Overall survival (OS)
    • To assess the safety and tolerability of NUFIRI-bev compared to FOLFIRI-bev
    • To assess the PK of NUFIRI-bev
  • Locations


    Karmanos Cancer Institute - Detroit Headquarters

    4100 John R
    Detroit, MI 48201
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    Phone: 800-527-6266

    Karmanos Cancer Institute at Weisberg Cancer Center - Farmington Hills

    31995 Northwestern Hwy
    Farmington Hills, MI 48334
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    Phone: 800-527-6266