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  • A Phase II Study of GT103 in Combination with Pembrolizumab in Refractory, Metastatic Non-Small Cell Lung Cancer

    Cancer Categories
    • Lung
    Karmanos Trial ID
    • 2022-116
    NCT ID
    • NCT05617313
    Age Group
    • Adult
    Scope
    • National
    PhaseClick for Clinical Trial Phase DefinitionPhase II
    Includes controlled clinical studies conducted to evaluate the effectiveness of the drug for a particular indication or indications in participants with the disease or condition under study and to determine the common short-term side effects and risks.
    • Phase II
    Principal Investigator
    • Hirva
      Mamdani, M.D.

      Lung Cancer Screening, Oncology - Medical View Profile

    Objective:

    Primary Objectives:

    • Assess the objective response rate (ORR) of GT103 in
      combination with pembrolizumab in patients with
      immunotherapy refractory, advanced stage (III/IV) or
      recurrent non-small cell lung cancer (NSCLC).
    • Determine the safety and tolerability of GT103 in
      combination with pembrolizumab in patients with
      immunotherapy refractory, advanced stage (III/IV) or
      recurrent non-small cell lung cancer (NSCLC).

    Secondary Objectives:

    • Characterize the PK profile of GT103 in combination with
      pembrolizumab
    • Describe the Progression Free Survival (PFS) of patients
      treated with GT103 in combination with pembrolizumab
    • Describe the Overall Survival (OS) of patients treated with
      GT103 in combination with pembrolizumab
  • Locations

    Locations

    Karmanos Cancer Institute - Detroit Headquarters

    4100 John R
    Detroit, MI 48201
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    Phone: 800-527-6266

    Karmanos Cancer Institute at Weisberg Cancer Center - Farmington Hills

    31995 Northwestern Hwy
    Farmington Hills, MI 48334
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    Phone: 800-527-6266