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  • A Phase I/IIa First-in-Human Study of [212Pb]VMT-a-NET Targeted Alpha-Particle Therapy for Advanced SSTR2 Positive Neuroendocrine Tumors

    Cancer Categories
    • Gastrointestinal (GI),Lung
    Karmanos Trial ID
    • 2025-004
    NCT ID
    • NCT05636618
    Age Group
    • Adult
    Scope
    • National
    PhaseClick for Clinical Trial Phase DefinitionPhase I
    Includes initial studies to determine the metabolism and pharmacologic actions of drugs in humans, the side effects associated with increasing doses, and to gain early evidence of effectiveness; may include healthy participants and/or patients.
    • Phase I/II
    Principal Investigator

    Objective:

    Primary Objectives:

    • To evaluate the safety by rate of DLTs and AEs of [212Pb]VMT-α-NET in subjects with NETs.
    • To determine the recommended phase 2 dose (RP2D) of [212Pb]VMT-α-NET in PRRT-naïve subjects with NETs.
    • To determine the PK properties of [212Pb]VMT-α-NET.
    • To determine the ORR by RECIST v1.1 in subjects with NETs receiving [212Pb]VMT-α-NET in the dose-expansion phase.

    Secondary Objectives:

    • To determine the ORR by RECIST v1.1 in subjects with NETs receiving [212Pb]VMT-α-NET in the dose-escalation phase.
    • To determine the DOR by RECIST v1.1 in subjects with NETs receiving [212Pb]VMT-α-NET.
    • To determine the PFS by RECIST v1.1 in subjects with NETs receiving [212Pb]VMTα-NET.
    • To determine the OS in subjects with NETs receiving [212Pb]VMT-α-NET.
  • Locations

    Locations

    Karmanos Cancer Institute - Detroit Headquarters

    4100 John R
    Detroit, MI 48201
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    Karmanos Cancer Institute at Weisberg Cancer Center - Farmington Hills

    31995 Northwestern Hwy
    Farmington Hills, MI 48334
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