Having a large clinical trial portfolio means giving patients treatment options often not available anywhere else, and years before they become the standard of care. To learn more about Karmanos Cancer Institute clinical trials or to see if a trial is right for you, please call 1-800-KARMANOS (1-800-527-6266) or request an appointment below
  • A Phase 1, First-in-Human, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Activity of XmAb®662 in Monotherapy or in combination with Pembrolizumab in Advanced Solid Tumors

    Cancer Categories
    • Breast,Gastrointestinal (GI),Genitourinary (GU),Gynecologic,Head and Neck,Lung,Skin
    Karmanos Trial ID
    • 2023-034
    NCT ID
    • NCT05996445
    Age Group
    • Adult
    • National
    PhaseClick for Clinical Trial Phase DefinitionPhase I
    Includes initial studies to determine the metabolism and pharmacologic actions of drugs in humans, the side effects associated with increasing doses, and to gain early evidence of effectiveness; may include healthy participants and/or patients.
    • Phase I
    Principal Investigator


    Primary Objectives

    • To identify the RD(s) and schedule(s) that is safe and biologically effective for XmAb662 administered by intravenous (IV) dosing in monotherapy or incombination with pembrolizumab administered by IV dosing
    • To assess the safety and tolerability of XmAb662 in monotherapy or combination with pembrolizumab in subjects with advanced solid tumors

    Secondary Objectives

    • To characterize the pharmacokinetics (PK) and immunogenicity of XmAb662 as monotherapy and in combination with pembrolizumab
    • To preliminarily assess antitumor activity of XmAb662 in monotherapy and in combination with pembrolizumab
  • Locations


    Karmanos Cancer Institute - Detroit Headquarters

    4100 John R
    Detroit, MI 48201
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    Phone: 800-527-6266

    Karmanos Cancer Institute at Weisberg Cancer Center - Farmington Hills

    31995 Northwestern Hwy
    Farmington Hills, MI 48334
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    Phone: 800-527-6266