A Phase 2, multicenter, open-label study of lifileucel (tumor-infiltrating lymphocytes [TIL]) in participants with previously treated advanced endometrial cancer

Cancer Categories

Karmanos Trial ID

NCT ID

Age Group

Scope

Phase

Principal Investigator

Primary Objectives:

To evaluate the efficacy of lifileucel as measured by ORR per RECIST v1.1 in participants with dMMR or pMMR tumors based on the central laboratory assessment of MMR status

Secondary Objectives:

To evaluate the efficacy of lifileucel as measured by CR rate, DOR, DCR, PFS, and OS in participants with dMMR or pMMR tumors based on the central laboratory assessment of MMR status
To demonstrate safety and tolerability of lifileucel in participants with advanced endometrial cancer

Eligibility

Inclusion Criteria:

Participants must have a histologically confirmed diagnosis of endometrial carcinoma. All histologies, including carcinosarcoma, will be allowed. Uterine sarcoma will not be allowed.
Participants who have received the following previous therapy:

Up to 3 lines of systemic therapy with no more than 1 line of chemotherapy for recurrent, metastatic, or primary unresectable disease. Prior hormonal therapy is allowed and do not count as prior lines of therapy.
Participants have progressed on or after platinum-based chemotherapy and anti-PD-1/PD-L1 therapy. Platinum-based chemotherapy and anti-PD-1/PD-L1 therapy may have been given together or in separate lines of therapy.
Participants must have documented radiographic disease progression during or after the last line of therapy.

Participants who have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 and estimated life expectancy of >6 months.
Participants having at least one resectable lesion and at least one measurable lesion, following resection of the lesion for TIL generation.
Participants who have adequate organ function, including adequate cardiopulmonary function.
Participants of childbearing potential must be willing to practice an approved method of highly effective birth control during treatment and up to 12 months after the last dose of study intervention.
Participants who are >70 years of age may be allowed to enroll after the investigator discusses with the medical monitor.

Exclusion Criteria:

Participants who have symptomatic untreated brain metastases.
Participants who have had a history of allogeneic organ transplant or any form of cell therapy involving prior conditioning chemotherapy within the past 20 years.
Participants who require systemic steroid therapy > 10 mg/day prednisone or another steroid equivalent dose.
Participants who have any form of primary immunodeficiency.
Participants who have another primary malignancy within the previous 3 years.

Locations

4100 John R
Detroit, MI 48201
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Phone: 1-800-527-6266

31995 Northwestern Hwy
Farmington Hills, MI 48334
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Phone: 1-800-527-6266

Applicable Disease Site

Therapies, Drugs, Devices