Having a large clinical trial portfolio means giving patients treatment options often not available anywhere else, and years before they become the standard of care. To learn more about Karmanos Cancer Institute clinical trials or to see if a trial is right for you, please call 1-800-KARMANOS (1-800-527-6266) or request an appointment below
  • A Phase 3, Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial of Selinexor in Maintenance Therapy After Systemic Therapy for Patients With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

    Cancer Categories
    • Gynecologic
    Karmanos Trial ID
    • GOG-3083
    NCT ID
    • NCT05611931
    Age Group
    • Adult
    Scope
    • National
    PhaseClick for Clinical Trial Phase DefinitionPhase III
    Includes trials conducted after preliminary evidence suggesting effectiveness of the drug has been obtained, and are intended to gather additional information to evaluate the overall benefit-risk relationship of the drug
    • Phase III
    Principal Investigator
    • Radhika
      Gogoi, M.D., Ph.D.

      Oncology - Gynecologic, Oncology - Surgical View Profile

    Objective:

    Primary Objectives:

    • To evaluate the efficacy of selinexor compared to placebo as maintenance therapy

    Key Secondary Objectives:

    • To compare overall OS in selinexor and placebo arms

    Secondary Objectives:

    • To evaluate the safety and tolerability of selinexor
    • To compare selinexor and placebo for time to first subsequent therapy
    • To compare selinexor and placebo for time to second subsequent therapy
    • To compare selinexor and placebo for time until second progression
    • To assess the efficacy of selinexor compared to placebo, as assessed by a blinded independent central review (BICR)
    • To evaluate health-related quality of life (HRQoL) outcomes
  • Locations

    Locations

    Karmanos Cancer Institute - Detroit Headquarters

    4100 John R
    Detroit, MI 48201
    Get Directions
    Phone: 800-527-6266

    Karmanos Cancer Institute at Weisberg Cancer Center - Farmington Hills

    31995 Northwestern Hwy
    Farmington Hills, MI 48334
    Get Directions
    Phone: 800-527-6266