Having a large clinical trial portfolio means giving patients treatment options often not available anywhere else, and years before they become the standard of care. To learn more about Karmanos Cancer Institute clinical trials or to see if a trial is right for you, please call 1-800-KARMANOS (1-800-527-6266) or request an appointment below
  • A Phase 1 Trial of MK-7684 as Monotherapy and in Combination with Pembrolizumab in Subjects with Advanced Solid Tumors

    Cancer Categories
    • Breast,Gastrointestinal (GI),Genitourinary (GU),Gynecologic,Head and Neck,Lung,Neurological
    Karmanos Trial ID
    • 2017-088
    NCT ID
    • NCT02964013
    Age Group
    • Adult
    Scope
    • National
    PhaseClick for Clinical Trial Phase DefinitionPhase I
    Includes initial studies to determine the metabolism and pharmacologic actions of drugs in humans, the side effects associated with increasing doses, and to gain early evidence of effectiveness; may include healthy participants and/or patients.
    • Phase I
    Principal Investigator
    • Ira
      Winer, M.D., Ph.D.

      Oncology - Gynecologic, Oncology - Surgical View Profile

    Objective:

    Primary:
    1. Objective: To determine the safety and tolerability of MK-7684 monotherapy and to establish an RPTD
    2. Objective: To determine the safety and tolerability of MK-7684 in combination with pembrolizumab and to establish an RPTD for MK-7684 when used in combination with pembrolizumab
    Secondary:
    1. Objective: To characterize the pharmacokinetic (PK) profiles of MK-7684 when used as monotherapy and in combination with pembrolizumab
    2. Objective: To characterize the PK profile of pembrolizumab after administration of MK-7684 in the combination treatment arm
    3. Objective: To evaluate the anti-tumor activity of MK-7684 when used as monotherapy and in combination with pembrolizumab using Response Evaluat ion Criteria in Solid Tumors (RECIST, version 1.1) as assessed by investigator review and measured by overall response rate (ORR)
  • Locations

    Locations

    Karmanos Cancer Institute - Detroit Headquarters

    4100 John R
    Detroit, MI 48201
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    Phone: 800-527-6266

    Karmanos Cancer Institute at Lawrence and Idell Weisberg Cancer Treatment Center - Farmington Hills

    31995 Northwestern Hwy
    Farmington Hills, MI 48334
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    Phone: 800-527-6266