Having a large clinical trial portfolio means giving patients treatment options often not available anywhere else, and years before they become the standard of care. To learn more about Karmanos Cancer Institute clinical trials or to see if a trial is right for you, please call 1-800-KARMANOS (1-800-527-6266) or request an appointment below
  • Open Label Phase II Trial of Cabozantinib in Patients with Metastatic Castrate Resistant Prostate Cancer (mCRPC) and Known Amplifications or Activating Mutations in Gene Targets of Cabozantinib who have Received Prior Anti-Androgen Therapy

    Cancer Categories
    • Genitourinary (GU)
    Karmanos Trial ID
    • 2021-048
    NCT ID
    • NCT04631744
    Age Group
    • Adult
    • National
    PhaseClick for Clinical Trial Phase DefinitionPhase II
    Includes controlled clinical studies conducted to evaluate the effectiveness of the drug for a particular indication or indications in participants with the disease or condition under study and to determine the common short-term side effects and risks.
    • Phase II
    Principal Investigator


    Primary Objectives:

    • To demonstrate that at least 75% of patients with metastatic castrate resistant prostate cancer who have progressed on an androgen receptor antagonist whose tumor possess a molecular alteration that is targeted by cabozantinib will be progression-free via PCWG3-modified RECIST 1.1 imaging (i.e. rPFS) after 6 months of cabozantinib therapy

    Secondary Objectives:

    • To assess PSA decline by PCWG3 criteria
    • To assess objective response proportion
    • To measure overall survival (OS)
    • To determine CTC response rate, as defined by conversions from >5 CTCs to <5 CTCs/7.5 mL whole blood and/or conversion from detectable (>0) to undetectable (<0) at 12 weeks
  • Locations


    Karmanos Cancer Institute - Detroit Headquarters

    4100 John R
    Detroit, MI 48201
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    Phone: 800-527-6266

    Karmanos Cancer Institute at Weisberg Cancer Center - Farmington Hills

    31995 Northwestern Hwy
    Farmington Hills, MI 48334
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    Phone: 800-527-6266