Having a large clinical trial portfolio means giving patients treatment options often not available anywhere else, and years before they become the standard of care. To learn more about Karmanos Cancer Institute clinical trials or to see if a trial is right for you, please call 1-800-KARMANOS (1-800-527-6266) or request an appointment below
  • Open-Label, Multicenter, Phase 1 Study to Assess the Safety of P-BCMA-ALLO1 in Subjects with Relapsed / Refractory Multiple Myeloma (MM)

    Cancer Categories
    • Hematologic (Blood Cancers)
    Karmanos Trial ID
    • 2022-032
    NCT ID
    • NCT04960579
    Age Group
    • Adult
    • National
    PhaseClick for Clinical Trial Phase DefinitionPhase I
    Includes initial studies to determine the metabolism and pharmacologic actions of drugs in humans, the side effects associated with increasing doses, and to gain early evidence of effectiveness; may include healthy participants and/or patients.
    • Phase I
    Principal Investigator
    • Andrew
      Kin, M.D.

      Oncology - Hematology, Oncology - Medical View Profile


    Primary Objectives:

    The primary objective of this study is:

    • To assess the safety and maximum tolerated dose (MTD) of P-BCMA-ALLO1 based on dose limiting toxicities (DLT)

    Secondary Objectives:

    Secondary objectives of this study are to evaluate:

    • The safety of P-BCMA-ALLO1
    • The anti-myeloma effect of P-BCMA-ALLO1
    • The effect of cell dose to guide selection of doses for further assessment in Phase 2/3 studies

    Exploratory Objectives:

    Exploratory objectives of this study are to:

    • Evaluate the relationship between MM plasma cell BCMA expression, circulating soluble BCMA, and clinical response
    • Characterize the expansion and functional persistence of P-BCMA-ALLO1 cells
    • Evaluate the relationship between putative CRS markers and efficacy or safety
    • Evaluate the effect of rimiducid on P-BCMA-ALLO1 related AEs, if indicated
  • Locations


    Karmanos Cancer Institute - Detroit Headquarters

    4100 John R
    Detroit, MI 48201
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    Phone: 800-527-6266

    Karmanos Cancer Institute at Weisberg Cancer Center - Farmington Hills

    31995 Northwestern Hwy
    Farmington Hills, MI 48334
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    Phone: 800-527-6266