Having a large clinical trial portfolio means giving patients treatment options often not available anywhere else, and years before they become the standard of care. To learn more about Karmanos Cancer Institute clinical trials or to see if a trial is right for you, please call 1-800-KARMANOS (1-800-527-6266) or request an appointment below
  • IMPACT: Immunotherapy in Patients with Metastatic Cancers and CDK12 Mutations

    Cancer Categories
    • Genitourinary (GU)
    Karmanos Trial ID
    • 2019-027
    NCT ID
    • NCT03570619
    Age Group
    • Adult
    Scope
    • National
    PhaseClick for Clinical Trial Phase DefinitionPhase II
    Includes controlled clinical studies conducted to evaluate the effectiveness of the drug for a particular indication or indications in participants with the disease or condition under study and to determine the common short-term side effects and risks.
    • Phase II
    Principal Investigator

    Objective:

    Primary Objective(s):
    • To determine the efficacy of checkpoint inhibitor immunotherapy with nivolumab and ipilimumab combination therapy followed by nivolumab monotherapy in patients with metastatic prostate cancer harboring loss of CDK12 function.
    Secondary Objective(s):
    • To determine the efficacy of checkpoint inhibitor immunotherapy with nivolumab and ipilimumab combination therapy followed by nivolumab monotherapy in patients with metastatic non-prostate cancer harboring loss of CDK12 function.
    • To determine the safety and tolerability of nivolumab and ipilimumab combination therapy followed by nivolumab monotherapy in patients with metastatic cancers with loss of CDK12 function.
    • To evaluate other measures of clinical efficacy of checkpoint inhibitor immunotherapy in metastatic tumors with loss of CDK12 function.
    • To assess the Quality of Life (QoL) in subjects treated on protocol therapy.
  • Locations

    Locations

    Karmanos Cancer Institute - Detroit Headquarters

    4100 John R
    Detroit, MI 48201
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    Phone: 800-527-6266

    Karmanos Cancer Institute at Lawrence and Idell Weisberg Cancer Treatment Center - Farmington Hills

    31995 Northwestern Hwy
    Farmington Hills, MI 48334
    Get Directions
    Phone: 800-527-6266