Anthony Shields, M.D., Ph.D.

Dr. Shields' career has been dedicated to clinical research and the care of patients with colorectal, pancreatic and other gastrointestinal cancers. His experiences in research and the clinic make him painfully aware of the need to develop new approaches in understanding and overcoming resistance to treatment for patients with GI cancer. At Karmanos Cancer Institute and Wayne University School of Medicine he leads clinical research efforts through his roles as the Associate Center Director for Clinical Sciences, Program Leader in Molecular Imaging and Diagnostics and Professor of Oncology and Medicine. Dr. Shields training as a Medical Oncologist provides the insight to guide studies in patients with cancer and the foresight to design trials that are appropriate. He has a broad understanding in clinical sciences with experience that spans from protocol design and development to implementation from the local to the national level. He is the sub-chair for colorectal cancer at the Southwest Oncology Group (SWOG), and co-chair for a national adjuvant colon cancer study sponsored by the Cancer and Leukemia Group B (CALGB) and SWOG. He serves on the NCI Colon Task Force, which is charged with overseeing clinical research studies in colorectal cancer, and has served on the NCI Investigational Drug Steering Committee. In the clinic, his work concentrates on the treatment of patients with gastrointestinal (GI) cancer and he continues to develop and lead new clinical trials for GI tumors. This includes serving as a founding faculty member of the Clinical Trials Methodology Workshop under the sponsorships of the Radiological Society of North America (RSNA) and the National Cancer Institute, which is designed to mentor new faculty. As an Associate Center Director for Clinical Sciences, and member of the Human Investigation Committee Review Board, he helps to oversee a large number of clinical studies within our Institute and comprehends the complexities and challenges of the approaches to successful evaluation of new agents. Dr. Shields clearly has a crucial role in the design of cancer clinical trials. His laboratory research focuses on the development and testing of tracers for use with positron emission tomography (PET) for the assessment of a variety of tumors (e.g. brain, lung, breast, and prostate cancers) and their response to treatment. Dr. Shields led the development of FLT {3'-deoxy-3'-fluorothymidine}; a promising tracer for tumor proliferation, which has received an IND from the FDA and is being tested in centers worldwide. He serves on the Steering Committee of the American College of Radiology (ACRIN) and the National Oncology PET Registry (NOPR) and works to incorporate innovative imaging in the multicenter clinical trials. He is Senior Editor for Molecular Imaging and Biology and the Journal of Nuclear Medicine, and a reviewer for a number of journals, including the New England Journal of Medicine, Nature Medicine, and The Journal of Clinical Oncology. He has authored over 100 peer-reviewed articles and more than 20 book chapters, reviews and case reports on cancer research.

Related News

November 25, 2023
IN THE NEWS: Advancements in liver cancer treatment brings hope for Black patients

Michigan Chronicle About 90% of liver cancer cases are hepatocellular carcinoma (HCC). The Michigan Chronicle looks at how more African Americans are diagnosed with liver cancer than White Americans. The new TheraBionic P1 medical device that Karmanos will offer patients in 2024 is FDA approved to treat this advanced-stage liver cancer after patients have failed first- and second-line treatment options. Boris Pasche, M.D., Ph.D., FACP , president and CEO at Karmanos, and Anthony Shields, M.D., Ph.D. , m...
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November 20, 2023
Karmanos Cancer Institute recognizes Pancreatic Cancer Awareness Month

The Barbara Ann Karmanos Cancer Institute , along with cancer centers and other organizations across the nation, recognizes November as Pancreatic Cancer Awareness Month. As its name indicates, pancreatic cancer originates in the pancreas, an organ that sits behind the stomach. The pancreas aids in digestion and helps regulate blood sugar. About Pancreatic Cancer Exocrine cells make up the majority of the pancreas. When these cells grow out of control, adenocarcinoma of the pancreas occurs. Pancreatic a...
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November 13, 2023
IN THE NEWS: Karmanos Cancer Institute first in nation to offer new liver cancer treatment

DBusiness Karmanos Cancer Institute in Detroit will be the first provider to offer the TheraBionic P1 medical device for the treatment of advanced hepatocellular carcinoma, the most common type of liver cancer. Boris Pasche, M.D., Ph.D., FACP , president and CEO at Karmanos, and Anthony Shields, M.D., Ph.D. , medical oncologist and leader of the Gastrointestinal and Neuroendocrine Oncology Multidisciplinary Team , explain the device's benefits to patients 18 years and older who have failed first- ...
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Awards

Heroes of Cancer Michael J. Brennan Award for Scientific Distinction, 2017
2005, 2009-2015 Voted one of the Best Doctor's in America by Best Doctors Inc.
2012, 2013 Selected by Castle Connolly Medical Ltd. as one of the region's Top Doctors
2007 Wayne State University Distinguished Faculty Fellowship Award
2005 European Association of Nuclear Medicine and Springer-Verlag Award - Best Clinical Paper
2005 Peter Valk Distinguished Clinical Scientist Award, Academy of Molecular Imaging

Professional Memberships

American Society of Clinical Oncology
American Society of Hematology
Society of Nuclear Medicine
American Association for Cancer Research
American Society for Microbiology
World Molecular Imaging Society

Publications

Wang J, Xiu J, Baca Y, Battaglin F, Arai H, Kawanishi N, Soni S, Zhang W, Millstein J, Salhia B, Goldberg RM, Philip PA, Seeber A, Hwang JJ, Shields AF, Marshall JL, Astsaturov I, Craig Lockhart A, Gatalica Z, Michael Korn W, Lenz HJ. Large-scale analysis of KMT2 mutations defines a distinctive molecular subset with treatment implication in gastric cancer. Oncogene. 2021 Jul;40(30):4894-4905. doi: 10.1038/s41388-021-01840-3. Epub 2021 Jun 23. PMID: 34163031
Wagner AJ, Severson PL, Shields AF, Patnaik A, Chugh R, Tinoco G, Wu G, Nespi M, Lin J, Zhang Y, Ewing T, Habets G, Burton EA, Matusow B, Tsai J, Tsang G, Shellooe R, Carias H, Chan K, Rezaei H, Sanftner L, Marimuthu A, Spevak W, Ibrahim PN, Inokuchi K, Alcantar O, Michelson G, Tsiatis AC, Zhang C, Bollag G, Trent JC, Tap WD. Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial. JAMA Oncol. 2021 Sep 1;7(9):1343-1350. doi: 10.1001/jamaoncol.2021.2086. PMID: 34236401
Vonderheide RH, Kraynyak KA, Shields AF, McRee AJ, Johnson JM, Sun W, Chintakuntlawar AV, Pawlicki J, Sylvester AJ, McMullan T, Samuels R, Kim JJ, Weiner D, Boyer JD, Morrow MP, Humeau L, Skolnik JM. Phase 1 study of safety, tolerability and immunogenicity of the human telomerase (hTERT)-encoded DNA plasmids INO-1400 and INO-1401 with or without IL-12 DNA plasmid INO-9012 in adult patients with solid tumors. J Immunother Cancer. 2021 Jul;9(7):e003019. doi: 10.1136/jitc-2021-003019. PMID: 34230114
Wang JY, Xiu J, Baca Y, Arai H, Battaglin F, Kawanishi N, Soni S, Zhang W, Millstein J, Shields AF, Grothey A, Weinberg BA, Marshall JL, Lou E, Khushman M, Sohal DPS, Hall MJ, Oberley M, Spetzler D, Shen L, Korn WM, Lenz HJ. Distinct genomic landscapes of gastroesophageal adenocarcinoma depending on PD-L1 expression identify mutations in RAS-MAPK pathway and TP53 as potential predictors of immunotherapy efficacy. Ann Oncol. 2021 Jul;32(7):906-916. doi: 10.1016/j.annonc.2021.03.203. Epub 2021 Mar 30. PMID: 33798656
Meyerhardt JA, Shi Q, Fuchs CS, Meyer J, Niedzwiecki D, Zemla T, Kumthekar P, Guthrie KA, Couture F, Kuebler P, Bendell JC, Kumar P, Lewis D, Tan B, Bertagnolli M, Grothey A, Hochster HS, Goldberg RM, Venook A, Blanke C, O'Reilly EM, Shields AF. Effect of Celecoxib vs Placebo Added to Standard Adjuvant Therapy on Disease-Free Survival Among Patients With Stage III Colon Cancer: The CALGB/SWOG 80702 (Alliance) Randomized Clinical Trial. JAMA. 2021 Apr 6;325(13):1277-1286. doi: 10.1001/jama.2021.2454. PMID: 33821899

Provider Profile:
Anthony Shields, M.D., Ph.D.