Microscopy, Imaging and Cytometry Resources Core

Microscopy, Imaging and Cytometry Resources Core

Mission of the Core

The mission of the Microscopy, Imaging & Cytometry Resources (MICR) core is to enhance the peer reviewed funded research activities of Karmanos Cancer Institute members whose research requires confocal microscopy, flow cytometry, small animal imaging and related techniques. We provide Karmanos members with expert scientific consultation and access to state-of-the-art instrumentation.

Microscopy, Imaging and Cytometry Resources Core is supported, in part, by NIH Center grant P30 CA022453 to the Karmanos Cancer Institute at Wayne State University.

Core Services Available

  • Confocal Microscopy, including both point scanning and spinning disk technologies
  • Multiphoton Microscopy, including Second Harmonic Generation imaging
  • Conventional, widefield epifluorescence
  • Optical sectioning using Structured Illumination (via the Zeiss ApoTome system) In vivo small animal SPECT/CT
  • In vivo small animal and large animal PET/CT
  • In vivo small animal X-Ray, fluorescence, and bioluminescence imaging
    In vitro and in vivo X-Ray Irradiation
  • Multi-parameter Flow Cytometry
  • Cell Sorting
  • Imaging Cytometry
  • Advanced Data Analysis, including 3D and 4D image reconstruction and quantitative measurements
  • Expert consultation, including advice on application choice and experimental design
  • Instrument-specific training for users as well as workshops on data analysis and advanced techniques
  • Grant collaboration and assistance with application preparation

More Information

For more information on this core, please use the links below. 


Kamiar Moin, Ph.D.
Director, Microscopy, Imaging & Cytometry Resources Core

Jessica Back, Ph.D.
Associate Director, Microscopy, Imaging & Cytometry Resources Core

Microscopy, Imaging and Cytometry Resources Core Selected Publications 

Identification and functional impact of homo-oligomers of the human proton-coupled folate transporter. J Biol Chem 2012;287:4982-95. PMCID: PMC3281668
Authors: Hou Z, Desmoulin SK, Etnyre E, Olive M, Hsiung B, Cherian C, Wloszczynski PA, Moin K, Matherly LH.

Next-generation sequencing: a powerful tool for the discovery of molecular markers in breast ductal carcinoma in situ. Expert Rev Mol Diagn 2013;13:151-65. PMCID: PMC3804339
Authors: Kaur H, Mao S, Shah S, Gorski DH, Krawetz SA, Sloane BF, Mattingly RR.

Live-cell imaging of tumor proteolysis: Impact of cellular and non-cellular microenvironment. Biochim Biophys Acta 2012;1824:123-32. PMCID: PMC3232330
Authors: Rothberg JM, Sameni M, Moin K, Sloane BF.

Comedo-DCIS is a precursor lesion for basal-like breast carcinoma: identification of a novel p63/Her2/neu expressing subgroup. Oncotarget 2013;4:231-41. PMCID: PMC3712569
Authors: Shekhar MP, Kato I, Nangia-Makker P, Tait L.

Cellular and computational studies of proteasome inhibition and apoptosis induction in human cancer cells by amino acid Schiff base-copper complexes. J Inorg Biochem 2013;118:83-93. PMCID: PMC3676669
Authors: Zuo J, Bi C, Fan Y, Buac D, Nardon C, Daniel KG, Dou QP.