Molecular Therapeutics Theme 3 Accomplishments

Theme 3: Validate clinical effectiveness of new agents and new protocols in interventional treatment trials

Scientific Accomplishments

In preclinical triple-negative breast cancer (TNBC) models, Drs. Boerner, Polin and Heilbrun, working with Dr. LoRusso, found that poly (ADP-ribose) polymerase (PARP) inhibitors such as veliparib (ABT-888) enhanced the activity of the topoisomerase 1 inhibitor irinotecan (CPT-11). Based on these results, a Phase I clinical trial was performed to examine the tolerability of combined veliparib/ironotecan in advanced solid tumor patients. Following the dose-escalation phase, an expansion cohort was opened to perform further biomarker and genomic correlative studies in two specific TNBC populations with the combined veliparib/irinotecan.

  • Lead researchers - Drs. Boerner, Polin and Heilbrun.
  • Collaborative researcher - Dr. Li

Dr. Gadgeelwas a Principal Investigators on a phase I/II study evaluating CH5424802 (alectinib), a second generation ALK (anaplastic lymphoma kinase) inhibitor in patients with ALK positive NSCLC (non-small cell lung cancer) whose disease had progressed following treatment with the first generation ALK inhibitor crizotinib. Based on the results of the phase II trial, the drug has received ‘breakthrough designation’ by the US FDA.

  • Lead researchers - Dr. Gadgeel

The Latest From Karmanos Cancer Institute

News

Beating back cancer

“To hear that was a godsend.” It was a familiar face that delivered the news to Lori. It was Nov. 29, and Lori was sitting in the McLaren Oakland ...

Read More

Johanna’s Legacy: Tribute gift supports better treatments for ovarian cancer

Give women the facts and they will take care of their health. That’s the premise behind the philanthropic drive of Sheryl Silver, a leading nation...

Read More

Time to Do a Skin Check

“Right now is a good time to take inventory of your skin.” There was plenty of sun in Michigan this summer. Spending more time outdoors and enjoyi...

Read More
News

ACS CAN Michigan Candid Connection, August 2021 — April Brown

Listen Now

Dr. Al Hallak on alcohol and cancer with WJR

Listen Now

ACS CAN MI CANdid Connection, July 2021 — Anthony Shields, M.D.

Listen Now