Tumor Biology and Microenvironment Program Themes

Tumor Biology and Microenvironment Program Themes

Theme 1: To identify molecular, cellular determinants of malignancy (metastasis drivers)

Our investigators study key signaling pathways involved in tumorigenicity, tumor cell phenotypical plasticity, and tumor cell drug response (metastasis operatives).

Theme 1 Accomplishments 

Theme 2: To identify and exploit the underlying mechanisms of tumor metastasis (operatives)

Our investigators study the function and underlying mechanisms such as the extracellular proteolysis/signaling network that enable tumor cells to adapt to and eventually overcome the varying microenvironments.

Theme 2 Accomplishments 

Theme 3: To identify and exploit stromal reactivity and host immunity to tumor progression (host response to metastatic tumors)

Our investigators study the interaction of tumor cells with mesenchyme and innate immune cells. We also identify, evaluate and utilize adaptive cellular and humoral immune responses to develop immunotherapy approaches.

Theme 3 Accomplishments 

The Latest From Karmanos Cancer Institute

News

Karmanos Cancer Institute presents 2021 Heroes of Cancer Awards

The Barbara Ann Karmanos Cancer Institute is pleased to announce the winners of its 2021 Heroes of Cancer Awards. This year's event celebrates Kar...

Read More

Karmanos Cancer Institute partners with The Toledo Clinic to establish a new cancer center in Northwest Ohio

The Barbara Ann Karmanos Cancer Institute is pleased to announce that it has entered into a partnership with The Toledo Clinic to establish a new ...

Read More

Father with colorectal cancer gives credit to daughter for saving his life

After serving for 20 years in the United States Navy as a submarine sailor, John Lacks retired and transitioned to life with his family, including...

Read More