Tumor Biology and Microenvironment Program Themes

Theme 1: To identify molecular, cellular determinants of malignancy (metastasis drivers)

Our investigators study key signaling pathways involved in tumorigenicity, tumor cell phenotypical plasticity, and tumor cell drug response (metastasis operatives).

Theme 1 Accomplishments 

Theme 2: To identify and exploit the underlying mechanisms of tumor metastasis (operatives)

Our investigators study the function and underlying mechanisms such as the extracellular proteolysis/signaling network that enable tumor cells to adapt to and eventually overcome the varying microenvironments.

Theme 2 Accomplishments 

Theme 3: To identify and exploit stromal reactivity and host immunity to tumor progression (host response to metastatic tumors)

Our investigators study the interaction of tumor cells with mesenchyme and innate immune cells. We also identify, evaluate and utilize adaptive cellular and humoral immune responses to develop immunotherapy approaches.

Theme 3 Accomplishments 

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Karmanos, WSU Researcher Receives NIH Award to Explore Socio-genomic Factors of Local Endometrial Cancer Survival Rates

The National Cancer Institute of the National Institutes of Health has awarded Anna Gottschlich, Ph.D., M.P.H., member of the Population Studies a...

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Registration Now Open: Karmanos and Wayne State University’s 3rd Annual Lung Cancer Symposium

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Karmanos Assistant Director of Clinical Outreach Accepted into Prestigious Executive Leadership in Academic Medicine Program

Latonya Riddle-Jones, M.D., MPH, assistant director of Clinical Outreach at the Barbara Ann Karmanos Cancer Institute and associate professor of I...

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