Molecular Therapeutics Selected Publications

Molecular Therapeutics Selected Publications

Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice. Gastroenterology. 2013;144(2):447-56.
Authors: Azmi AS, Aboukameel A, Bao B, Sarkar FH, Philip PA, Kauffman M, Shacham S, Mohammad RM.

Regulation of metformin response by breast cancer associated gene 2. Neoplasia. 2013;15(12):1379-90.
Authors: Buac D, Kona FR, Seth AK, Dou QP.

Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study. Lancet Oncol. 2014;15(10):1119-28.
Authors: Gadgeel SM, Gandhi L, Riely GJ, Chiappori AA, West HL, Azada MC, Morcos PN, Lee RM, Garcia L, Yu L, Boisserie F, Di Laurenzio L, Golding S, Sato J, Yokoyama S, Tanaka T, Ou SH.

Therapeutic targeting of a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter. Mol. Pharmacol. 2011; 80(6):1096-107. 
Authors: Kugel Desmoulin S, Wang L,  Hales E,  Polin L, White K, Kushner J, Stout M,  Hou Z, Cherian, C, Gangjee A, Matherly LH.

The ETS domain transcription factor ELK1 directs a critical component of growth signaling by the androgen receptor in prostate cancer cells. J Biol Chem. 2013;288(16):11047-65.
Authors: Patki M, Chari V, Sivakumaran S, Gonit M, Trumbly R, Ratnam M.

Glucocorticoid receptor status is a principal determinant of variability in the sensitivity of non-small cell lung cancer cells to pemetrexed. J Thoracic Oncol. 2014; 9: 519-26.
Authors: Patki M, Gadgeel S, Huang Y, McFall T, Shields AF, Matherly LH, Bepler G, Ratnam M.

Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011;286:38000-17.
Authors: Puliyappadamba VT, Wu W, Bevis D, Zhang L, Polin L, Kilkuskie R, Finley RL Jr, Larsen SD, Levi E, Miller FR, Wali A, Rishi AK.

Novel inhibitors of Rad6 ubiquitin conjugating enzyme: design, synthesis, identification, and functional characterization. Mol Cancer Ther. 2013;12(4):373-83.
Authors: Sanders MA, Brahemi G, Nangia-Makker P, Balan V, Morelli M, Kothayer H, Westwell AD, Shekhar MP.

Role of autophagy in cisplatin resistance in ovarian cancer cells. J Biol Chem. 2014; 289:17163-73.
Authors: Wang J, Wu GS.

Synthesis and biological activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry. J Med Chem. 2010; 53: 1306-18.
Authors: Wang L, Cherian C, Desmoulin SK, Polin L, Deng Y, Wu J, Hou Z, White K, Kushner J, Matherly LH, Gangjee A.

Implications of plasma protein binding for pharmacokinetics and pharmacodynamics of the γ-secretase inhibitor RO4929097. Clin Cancer Res. 2012; 18: 2066-79.
Authors: Wu J, Lorusso PM, Matherly LH, Li J.

Regulation of the Src-PP2A interaction in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. J Biol Chem. 2013; 288: 33263-71.
Authors: Xu J, Xu Z, Zhou JY, Zhuang Z, Wang E, Boerner J, Wu GS.

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