Molecular Therapeutics Research Program

Mission

The underlying mission of the Molecular Therapeutics (MT) Program is to translate laboratory findings to the clinic so as to improve the lives of patients with cancer by identifying new molecules, targets and strategies for treating cancer. This highly interactive program includes a cross section of laboratory-based scientists and physicians at Karmanos who meet regularly through programmatic activities, and serve as co-investigators on research grants and investigator-initiated clinical trials.

The MT Program’s overriding goal is to integrate basic and translational scientists working broadly in areas of drug development, new or established therapeutic targets or pathways, and cellular and genetic biomarkers of cancer, with physicians conducting interventional treatment trials at the Karmanos Cancer Institute.  

Scientific Themes

  1. Identify and validate new tumor targets and pathways and develop novel candidate therapeutics.
  2. Develop new imaging agents and technologies for cancer diagnosis and staging.
  3. Validate clinical effectiveness of new agents in interventional treatment trials.

Program Activities

The MT Program leadership actively supports:

  • Basic-clinical collaborations and translational research through the monthly program meetings
  • Molecular Therapeutics Special Seminars
  • Focused retreats
  • Small working groups or topical conferences
  • An annual Molecular Therapeutics Program Retreat
  • Targeted internal grants with emphasis on collaboration and translational science

Program Leaders

Yubin Ge, Ph.D.

Molecular Therapeutics Program Leader
Barbara Ann Karmanos Cancer Institute
Professor, Department of Oncology
Wayne State University School of Medicine
gey@karmanos.org

Eduard Chekmenev, Ph.D.

Molecular Therapeutics Program Co-Leader
Barbara Ann Karmanos Cancer Institute
Professor, Departments of Chemistry and Oncology
Wayne State University
chekmenev@wayne.edu

Hirva Mamdani, M.D.

Molecular Therapeutics Program Co-Leader
Thoracic Oncology Multidisciplinary Team Leader
Barbara Ann Karmanos Cancer Institute
Associate Professor, Departments of Medicine and Oncology
Wayne State University School of Medicine
mamdanih@karmanos.org

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